Design: GenoCAD – Rule-based genetic design tools user-friendly and Domain Specific Language M. Galdzicki, K. P. Clancy, E. Oberortner, M. Pocock, J. Y. Quinn, C. a Rodriguez, N. Roehner, M. L. Wilson, L. Adam, J. C. Anderson, B. a Bartley, J. Beal, D. Chandran, J. Chen, D. Densmore, D. Endy, R. Grünberg, J. Hallinan, N. …
Biosecurity for the Age of Redesigned Life.November 8, 2013 by JOHN DANKOSKY. NPR Science Friday (http://www.sciencefriday.com/segments/biosecurity-for-the-age-of-redesigned-life/) iGEM Team Developing Biosecurity Software for Synthetic Genomics.Jul 23, 2010 by Uduak Grace Thomas. (https://www.genomeweb.com/informatics/igem-team-developing-biosecurity-software-synthetic-genomics) Bioinformatics used to detect rogue use of synthetic biology. July 19-20, 2010 by Barry Whyte, Virginia Tech (PR). Biotechniques, Science Blog, e! Science News, R&D Mag, Eurekalert, ScienceDaily, …
Adam, L., Kozar, M., Letort, G., Mirat, O., Srivastava, A., Stewart, T., Wilson, M.L., Peccoud, J. (2011). Strengths and limitations of the federal guidance on synthetic DNA. Nature Biotechnology.
GenoTHREAT is now open source (find it on Source Forge). The press release: BLACKSBURG, Va., March 21, 2011 – A software package designed to minimize the potential risks of synthetic biology for the nation’s defense and security is now available to the gene synthesis industry and synthetic biology community in an open-source format. Virginia Tech …
Description at http://2010.igem.org/Team:VT-ENSIMAG/Genothreat Paper Adam, L., Kozar, M., Letort, G., Mirat, O., Srivastava, A., Stewart, T., Wilson, M.L., Peccoud, J. (2011). Strengths and limitations of the federal guidance on synthetic DNA. Nature Biotechnology. Code https://sourceforge.net/projects/genoguard/
The iGEM team was invited by the FBI to present their work to 30 representatives of 15 government agencies. And we visited the FBI headquarters!
The iGEM team already got results! Their project on GenoTHREAT is to be pursued: NSF awarded $1,000,000 to further develop the sequence screening software. More details: http://www.nsf.gov/awardsearch/showAward.do?AwardNumber=1060776
The team of students I am advising for iGEM 2010, VT-ENSIMAG biosecurity, is featured in this press release. They are working on implementing and characterizing the federal guidance on synthetic genomics and on building a corresponding software called GenoTHREAT. Learn more in BioTechniques and on Genomeweb.