Category: Synthetic Biology

Portfolio

The Synthetic Biology Open Language (SBOL) provides a community standard for communicating designs in synthetic biology

Authors: Michal Galdzicki, Kevin P Clancy, Ernst Oberortner, Matthew Pocock, Jacqueline Y Quinn, Cesar A Rodriguez, Nicholas Roehner, Mandy L Wilson, Laura Adam, J Christopher Anderson, Bryan A Bartley, Jacob Beal, Deepak Chandran, Joanna Chen, Douglas Densmore, Drew Endy, Raik Grünberg, Jennifer Hallinan, Nathan J Hillson, Jeffrey D Johnson, Allan Kuchinsky, Matthew Lux, Goksel Misirli, …

Development of a domain-specific genetic language to design Chlamydomonas reinhardtii expression vectors

Authors Mandy L Wilson, Sakiko Okumoto, Laura Adam, Jean Peccoud Publication date 2013/11/8 Journal Bioinformatics Volume30 Issue2 Pages 251-257 Abstract Motivation: Expression vectors used in different biotechnology applications are designed with domain-specific rules. For instance, promoters, origins of replication or homologous recombination sites are host-specific. Similarly, chromosomal integration or viral delivery of an expression cassette imposes specific …

A step-by-step introduction to rule-based design of synthetic genetic constructs using GenoCAD

Authors Mandy L Wilson, Russell Hertzberg, Laura Adam, Jean Peccoud Publication date 2011/1/1 Book Methods in enzymology Volume 498 Pages 173-188 GenoCAD is an open source web-based system that provides a streamlined, rule-driven process for designing genetic sequences. GenoCAD provides a graphical interface that allows users to design sequences consistent with formalized design strategies specific …

Formal grammars to protect intellectual properties in synthetic biology.

International Conference on Synthetic Biology at Evry, France, December 15-16, 2010. (invited talk+poster)

iGEM team helps prevent rogue use of synthetic biology

The team of students I am advising for iGEM 2010, VT-ENSIMAG biosecurity, is featured in this press release. They are working on implementing and characterizing the federal guidance on synthetic genomics and on building a corresponding software called GenoTHREAT. Learn more in BioTechniques and on Genomeweb.

Modeling structure-function relationships in synthetic DNA sequences using attribute grammars

Authors Yizhi Cai, Matthew W Lux, Laura Adam, Jean Peccoud Publication date 2009/10/9 Journal PLoS computational biology Volume5 Issue10 Pages e1000529 Abstract Recognizing that certain biological functions can be associated with specific DNA sequences has led various fields of biology to adopt the notion of the genetic part. This concept provides a finer level of granularity than the …