Low-cost, modular, multi-strain diagnostic (ongoing)
This is the application part of the project I am finishing. We engineered yeast to induce growth arrest using a number of genes/inducers that we then characterized. We then used them as a diagnostic tool. We used nonlinear differential equations. We model our co-culture experiments and made predictions. We used a flow cytometer to collect …
Synthetic control of yeast culture growth rates (ongoing)
I am finishing a project started as a postdoc in the Klavins Lab at UW with Orlando de Lange and Alberto Carignano that we are about to publish. We engineered yeast to induce growth arrest using a number of genes/inducers that we then characterized. We then used it in a cool application. I work both …
Design of Languages for Systems and Synthetic Biology
Context We propose to encompass context-dependent genomic information and mathematical models in a logical and structured fashion through the use of attribute grammars. Attribute Grammars (AG) provide means to compute a mathematical model (possibly encoding phenotypic traits) from a genetic construct. AGs are a framework for biological Domain Specifi c Languages (DSLs) that, unlike current formalisms …
Gro for snowflake yeast
Gro is a software written in C++ using QT. Gro is a programming language and a 2D simulation environment for cells. The physics and front end has been implemented for e.coli. Specification and simulation of synthetic multicelled behaviors. Jang SS(1), Oishi KT, Egbert RG, Klavins E. Author information: (1)Department of Electrical Engineering, University of Washington, …
[Slides] Formal languages to map Genotype to Phenotype in Natural Genomes.
Adam, L. Formal languages to map Genotype to Phenotype in Natural Genomes. GBCB seminar, 2012. Speaker: Laura Adam, GBCB Doctoral Candidate Advisor: Jean Peccoud, VBI Title: Formal languages to map Genotype to Phenotype in Natural Genomes Abstract: To formalize Genotype-to-Phenotype mapping and confer predictive powers, missing in current approaches, information from genomic databases and mathematical …
Modeling structure-function relationships in synthetic DNA sequences using attribute grammars
Authors Yizhi Cai, Matthew W Lux, Laura Adam, Jean Peccoud Publication date 2009/10/9 Journal PLoS computational biology Volume5 Issue10 Pages e1000529 Abstract Recognizing that certain biological functions can be associated with specific DNA sequences has led various fields of biology to adopt the notion of the genetic part. This concept provides a finer level of granularity than the …